English pdf, 627 kb superb foam with the pu fixed poker from basf. Poloxamer 407 pluronic f127 has been applied in a very broad range in biomedical and pharmaceutical industries torchilin et al. Among this family of copolymers, poloxamer 407 is a nonionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. As a highly elastic synthetic fiber, spandex, or elastane, is currently a very popular textile material.
Emm 070801e00 january 2008 page 4 of 10 pluracare lf grades poloxamer applications it is suggested that these pluracare copolymers be considered for their general functionality as surfactants, emulsifiers, solubilizers and stabilizers in almost all. They make this highlyefficient intermediate, used in many types of applications, significantly easier and safer to handle. Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide ppo flanked by two hydrophilic polyethyleneoxide peo blocks. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Assessment of transdermal penetration enhancement by topical. Easy preparation of poloxamer 407 based sterile injectable. Poloxamer 188, european pharmacopoeia ep reference standard. However, little is known in any quantitative sense of its effect on protein adsorption and aggregation. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4.
Poloxamer 188 basf pluronic f68 is widely used as a shear. Thermogelling properties of purified poloxamer 407 ncbi. Poloxamer 188 chemical information, properties, structures, articles, patents and more chemical data. Basf is the first company in the world to offer triphenylphosphine tpp in the form of pellets. Poloxamer is a common biopolymer in intradermal drugdelivery. Poloxamer 407 is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. At first glance, one might tend to believe that from the point of view of the gibbs. Among the poloxamers, poloxamer 407 with registered trademarks of pluronic f127 by basf laboratories and synperonic pef127 by icp. A supercritical fluid extraction process was used to prepare p188p. Mining solutions innovative chemistry meeting the challenges of mining industry customers basfs mining solutions business offers a diverse range of mineral processing and hydrometallurgical chemistries and technologies to improve process efficiencies and aid the economic extraction of valuable resources. It appears that your browser has javascript disabled.
Variability in poloxamer 188 p188 raw material, which is routinely used in cell culture media to protect cells from hydrodynamic forces, plays an important role in the process performance. The methods of determination are described in this monograph or in the general methods to be found in the european pharmacopoeia. In addition to poloxamer 188 nf, basf also offers comprehensive solutions to the pharmaceutical industry for both small and large molecule formulation needs. Modulation of protein adsorption by poloxamer 188 in. Sep 18, 2014 register now and get a free online msds binder. Pdf multiblock poloxamer surfactants suppress aggregation. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj introduction lutrol f grades are block copolymers referred to as poloxamers, consisting of polyoxyethylene. The ease of production, the stability at 4 c or at room temperature and the low cost of the formulation, when compared to the phospholipids used in the liposomal formulations, are attractive conditions. In the present study, a poloxamer 407based amphotericin b ampbcontaining polymeric micelles system ampbm was employed in the treatment of leishmania amazonensisinfected balbc mice. Dystrophic heart failure blocked by membrane sealant. Lutrol f 127 it is recommended to use a preparation of the poloxamer with the active. Poloxamer 407mediated alterations in the activities of enzymes regulating lipid metabolism in rats.
Multiblock poloxamer surfactants suppress aggregation of denatured proteins article pdf available in biochimica et biophysica acta 17801. Poloxamers are also known by the trade names synperonics, pluronic, and. Physical and chemical properties as described by leaf 1967, many poloxamers dissolve in water and form gels when a concentrated aqueous solution is made. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Poloxamer 188 and poloxamer 407 stock standards were prepared by dissolving 200 mg of poloxamer in 100 ml of water to make 2. Dystrophic heart failure blocked by membrane sealant poloxamer. If you decide to use photos or graphics belonging to inge gmbh, please clearly indicate this fact in the list of references or the image caption. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Poloxamer 188 emprove expert cell culture optimized cas 9003116 stabilized with 70 ppm bht find msds or sds, a coa, data sheets and more information. Poloxamer 407 pluronic f127based polymeric micelles for. Basf enlightens the auto industry altair engineering. In view of the many factors that may affect processing and application. There is a possibility that this would work better than injections.
The poloxamer synperonic f108 stock solution was stored at 4c. Apr 17, 2020 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. Basf to develop a high purity poloxamer for mast therapeutics. Basf offer all functional materials required for a successful formulation using melt granulation. Thermogelling properties of purified poloxamer 407. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c. The approximate lengths of the two peg blocks is 101 repeat units while the approximate length of the propylene. Poloxamer complete drug information, side effects and. You can find detailed information on our product range by looking up your industry or using our product finder. Rheology modifiers pdf, 859 kb rheology modifiers product recommendations for asia pacific pdf, 171 kb rheology modifiers product recommendations for europe pdf, 532 kb rheology modifiers product recommendations for north america pdf, 183 kb.
Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada ira j. Poloxamer 188 emprove expert cell culture optimized cas 9003. Poloxamers, available also under the trademark pluronics basf, are a class of watersoluble nonionic aba and bab triblock copolymers. Ch 3 hoch 2ch 2o xch 2cho ych 2ch 2o xh lutrol f 68 nf important. They are also used in topical dosage forms and rectal suppositories. German pdf, 6 mb english pdf, 6 mb chemistry creates versatility. Assessment of transdermal penetration enhancement by. Poloxamers are also known by the trade names synperonics. Modulation of protein adsorption by poloxamer 188 in relation. Poloxamer 407mediated alterations in the activities of.
The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407 3. Loratadine, solid dispersions, poloxamer 188, poloxamer 407. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene polypropylene oxide flanked by two hydrophilic chains of polyoxyethylene polyethylene oxide. Makon l61 poloxamer 181 liquid 3 2,000 24 32 162 makon l62 poloxamer 182 liquid 7 2,500 32 41 268 makon l64 poloxamer 184 liquid 15 2,900 58 18 312 makon l101 poloxamer 331 liquid 1 3,800 15 36 392 makon p6575 na paste 17 3,800 82 27 2222 makon p104 poloxamer 334 paste 5,900 82 32 4482 makon p105 poloxamer 335 paste 15 6,500 631 36 6262. Technical information pluracare lf grades poloxamer.
Poloxamer hydrogels for biomedical applications mdpi. They make this highlyefficient intermediate, used in many types of. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. Pge2 and poloxamer synperonic f108 enhance transduction of. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Quantitation of poloxamers in pharmaceutical formulations. Poloxamer is available in different grade based on the physical parameter like molecular weight, weight % of oxyethylene etc. Renewable content and high biodegradability make a range of basfs finished lubricants. Basf pharmaceuticalgrade ingredients for the dermatology industry.
Basf corporation evaluation of lutrol f grades prill vs. Learn about poloxamer from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Table 2 different poloxamine varieties commercialized by basf. Polythf for spandex and elastane basf intermediates. Mar 31, 2016 variability in poloxamer 188 p188 raw material, which is routinely used in cell culture media to protect cells from hydrodynamic forces, plays an important role in the process performance. Mechanism investigation for poloxamer 188 raw material. Pdf poloxamers, poloxamines and polymeric micelles.
The sales representative responsible for your area will be happy to answer any questions you may have about our products. The advantage of spandex is its elasticity, making spandexcontaining clothes very comfortable to wear. Poloxamer 407 has approximate block lengths of a 101 and b 56. Lutrol f 68 meets the requirements of the current uspnf family monograph, poloxamer. It is a surfactant functioning both as cleansing and solubilizing agent. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations kolliphor p 407 is also used as a polymeric solubilizer. Apart from its use in manual sugar coating, kollidon va 64 or kollidon 30. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. The high performance and safety of basf products is backed by comprehensive documentation so you know you can rely on us our flexible kolliphor solutions can be used for hotmelt and spraydrying processes basf poloxamers offer better solubilizing properties compared to hpmc, pvp and cyclodextrins. Pluracare f127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications.
Download brochures this page features a selection of our latest brochures. It possesses solubilizing, bodying and gelling properties. Besides clothing, spandex is being gradually applied in the medical and other industries. The synthetic lubricants also provide sustainability benefits, for example, by helping to improve energy efficiency which reduces fuel consumption and decreases co 2 emissions. Poloxamer 188 and 407 standards with concentrations of 1. Basfs finished lubricants ensure firstclass results in terms of gear wear, seal life, fluid oxidation and oil life. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Poloxamer 407 was a gift sample from basf corporation, mumbai. Effect of poloxamer on release of poorly water soluble drug. Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada. Differential effects of commercialgrade and purified. Fagron wants to widen the therapeutic scope of the.
Initially, the in vitro antileishmanial activity ic 50 value of ampbm and bampbm empty micelles against stationary promastigotes and amastigoteslike forms of the parasites was. Basf pharma ingredients and services offers our solutionsoriented skin delivery platform to formulators of otc and rx topical. Synthesis and characterization of poloxamer 188grafted. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Kolliphor p 407 is used primarily as thickening agent and gel former, as well as coemulsifier and consistency enhancer in creams and liquid emulsions. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Basf, ludwigshafen, germany was prepared in a stock solution of 100 mgml by dissolving it in sterile water overnight and filtering it through a 0. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407. Even though tremendous efforts have been spent to understand the mechanism of poloxamers protection, the root cause for lot. Poloxamer 105 benzoate is an ester of poloxamer 105 and benzoic acid and poloxamer 182 dibenzoate is the diester of poloxamer 182 and benzoic acid gottschalck and mcewen 2004. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj.
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